ALIGNMENT INDEPENDENT 3D-QSAR, QUANTUM CALCULATIONS AND MOLECULAR DOCKING OF MER SPECIFIC TYROSINE KINASE INHIBITORS AS ANTICANCER DRUGS

Alignment independent 3D-QSAR, quantum calculations and molecular docking of Mer specific tyrosine kinase inhibitors as anticancer drugs

Mer receptor tyrosine kinase is a promising novel cancer therapeutic target in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.3D-QSAR analyses based on alignment independent descriptors were performed on a series of 81 Mer specific tyrosine kinase inhibitors.The fractional factor

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A digital atlas to characterize the mouse brain transcriptome.

Massive amounts of data are being generated in an effort to represent for the brain the expression of all genes at cellular resolution.Critical to exploiting this effort is the ability to place these data into a common frame of reference.Here we have developed a computational method for annotating gene expression patterns in the context of a digita

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